Physical activity level, and musculoskeletal, respiratory, and cardiac function were not associated with fatigue. Lower functional ability was associated with greater fatigue by parent proxy‐report (ρ=0.26 p=0.03). Depressive symptoms were associated with greater fatigue by child self‐report (ρ=–0.46 p<0.001) and parent proxy‐report (ρ=–0.45 p<0.001).
Sleep disturbance symptoms were associated with greater fatigue by child self‐report (ρ=–0.42 p=0.003) and parent proxy‐report (ρ=–0.51 p<0.001). Patients with DMD across ages and disease stages experienced greater fatigue compared to typically developing controls from published data. Subjective fatigue was assessed using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale by child self‐report and parent proxy‐report. Seventy‐one patients (all males median age 12y, age range 5–17y) identified via the Canadian Neuromuscular Disease Registry, and their parents completed questionnaires. To describe fatigue in Duchenne muscular dystrophy (DMD) from patients’ and parents’ perspectives and to explore risk factors for fatigue in children and adolescents with DMD.Ī multicentre, cross‐sectional study design was used.
Total scores of the child and parent Italian versions of the PedsQL-MFS demonstrated good reliability and convergent validity in paediatric inpatients with obesity and their parents, and are complementary rather than interchangeable.Level of evidenceNo level of evidence. PedsQL-MFS total scores were strongly correlated with Somatic Complaints scores on the CBCL, and moderately associated with anxiety, depression, social problems and school problems.Conclusions Parent–child agreement was low with latent means higher for parent reports. Bifactor Analysis supported the multidimensionality and the reliability of the total and subscale scores as multidimensional composites. This study aimed to examine the factor structure, reliability, inter-rater agreement and convergent validity of the child and parent Italian versions of the paediatric quality of life inventory multidimensional fatigue scale (PedsQL-MFS) in paediatric inpatients with obesity and one of their parents.Methods100 pairs of children/adolescents (64% female, mean age = 15.34) with obesity and one of their parents completed the PedsQL-MFS and the Child Behaviour Checklist (CBCL) or the Youth Self Report.ResultsConfirmatory Factor Analysis indicated that the three correlated first-order factors model corresponding to the published subscales demonstrated acceptable fit and achieved strict invariance across parent and child informants. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc. The results demonstrate the relative severity of fatigue symptoms in pediatric patients with SCD, indicating the potential clinical utility of multidimensional assessment of fatigue in patients with SCD in clinical research and practice. The PedsQL™ Multidimensional Fatigue Scale demonstrated acceptable to excellent measurement properties in SCD.
Confirmatory factor analysis demonstrated an acceptable to excellent model fit in SCD. PedsQL™ Multidimensional Fatigue Scale Scores were significantly worse with large effects sizes (≥0.80) for patients with SCD than for a comparison sample of healthy children, supporting known-groups discriminant validity. Intercorrelations of the PedsQL™ Multidimensional Fatigue Scale with the PedsQL™ Generic Core Scales were predominantly in the large (≥0.50) range, supporting construct validity. The PedsQL™ Multidimensional Fatigue Scale evidenced excellent feasibility, excellent reliability for the Total Scale Scores (patient self-report α = 0.90 parent proxy-report α = 0.95), and acceptable reliability for the three individual scales (patient self-report α = 0.77-0.84 parent proxy-report α = 0.90-0.97). Participants also completed the PedsQL™ 4.0 Generic Core Scales. This was a cross-sectional multi-site study whereby 240 pediatric patients with SCD and 303 parents completed the 18-item PedsQL™ Multidimensional Fatigue Scale. The study objective was to report on the feasibility, reliability, and validity of the PedsQL™ Multidimensional Fatigue Scale in SCD for pediatric patient self-report ages 5-18 years and parent proxy-report for ages 2-18 years. Sickle cell disease (SCD) is an inherited blood disorder characterized by a chronic hemolytic anemia that can contribute to fatigue and global cognitive impairment in patients.
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